TILDEN INJECTION

TILDREN INJECTION

TRIDEN INJECTION

TREATMENT FOR LAMENESS ASSOCIATED WITH BONE AND CARTILAGE CHANGES IN HORSES

COMPOSITION
TILUDRONIC ACID 50mg/vial.


ACTIONS
Tiludronic acid belongs to the bisphosphonate therapeutic class, a class of product with activity on bone metabolism. The main pharmacological property of TILDREN Injection is to reduce bone resorption by inhibiting the activity of osteoclast.

TILDREN Injection acts as a regulator of bone remodelling in all situations involving excessive bone resorption. This regulator effect is not associated with a negative effect of bone formation or bone mineralisation at the recommended therapeutic dosage.

Areas of reduced bone density are a pathological change common to most cases of Navicular Disease and Bone spavin and are due to inappropriate resoption of bone (osteolysis). In double-blind, placebo-controlled clinical trials for both conditions, TILDREN treatment induced a clear improvement as demonstrated by long-term reduction in lameness and progressive resumption of sporting activity.


In another double-blind, placebo-controlled clinical trial into the treatment of back pain associated with bony lesions of the vertebral column, TILDREN treatment induced a clear improvement in back flexibility, however further research is required to add this indication as a registered claim. Other studies have shown that TILDREN treatment can prevent the bone loss, which usually occurs during inactivity in horses, as shown by measurements of bone density in spelling horses.

TILDREN Injection has also demostrated anti-arthritic properties in a model of poly-arthristis in rats. In vitro date identified inhibiting effects on the secretion of enzymes which degrade cartilage matrix.


INDICATIONS
HORSES: Treatment of lameness associated with bone and cartilage changes such as those observed in Navicular Disease and Bone Spavin.


DOSAGE AND ADMINISTRATION
DOSAGE: 0.1mg Tiludronic acid per kg bodyweight once daily for 10 days by slow intravenous injection. i.e. 10mL (1 vial) of reconstituted solution per 500kg bodyweight per day for 10 days.


PRESENTATION
CARTON CONTAINS: 10 vials of 50mg freeze-dried powder (Tildren) and 10 vails of 10mL solvent (Water for injection). Each carton provides a 10-day treatment course for a 500kg horse.


STORAGE
Store below 25 celcius (air conditioning) in outer carter.